Several studies have shown that supplementation of MSM significantly reduces joint degeneration and inflammation. After one month, both groups noted equal improvements in pain and stiffness 6.
In another experiment, mice with a predisposition to rheumatoid arthritis-like joint lesions were studied. The beneficial effect of MSM is due in part to its ability to improve cell permeability, allowing harmful substances lactic acid, toxins to flow out while permitting nutrients to flow in, thereby preventing a pressure buildup in cells that causes inflammation in the joints 5.
The mean life span of the control group was 5. The MSM group showed decreased anti-nuclear antibody responses and significant diminution of lymphadenopathy, splenomegaly and anemia development, thus suggesting that MSM provided significant protection against the development of the autoimmune disease ALD Other experiments were conducted on mice bred for their propensity to acquire the autoimmune disease Systemic Lupus Erythematosus SLE.
These experiments showed MSM to have a protective effect both before and after the onset of the disease. Several experiments have shown that oral administration of MSM can protect rats against the onset of cancer. In one study, rats specially bred to be susceptible to breast cancer when given certain carcinogenic compounds were fed a diet containing MSM for a period of eight days.
The control group did not receive MSM. Following this preliminary period, all rats were given oral doses of cancer-causing agents. There was no statistical difference in the number of tumors developing in the two groups.
However, the MSM diet rats developed their first tumors some days later than the control rats, and these tumors became cancerous some days later than those in the control group. Considering a two-year average life expectancy of rats, days are the equivalent of about ten years in human life 8. The control group received only tap water. One week after the start of the dietary regimen, all rats were injected with dimethylhydrazine, a chemical that induces colon cancer.
Over the nine months that the experiment was conducted, the number of bowel tumors occurring in the rats was statistically the same for the two groups. However, the time of appearance of the first bowel tumors was considerably longer in the MSM treated rats.
The researchers concluded that MSM significantly lengthens the time of tumor onset compared to the controls 8. One of the most amazing discoveries on MSM is its anti-parasitic action against Giardia, Trichomonas, roundworms, nematodes, Enterobius and other intestinal worms 5. Animal studies include laboratory mice determined to have pin worms Enterobius by fecal cast examination. After 17 days, fecal examination indicated the feces were free of worms and eggs.
Human studies include a man with confirmed Giardia lamblia , apparently contacted from contaminated water in a primitive area. He was given mg MSM three times a day for 14 days. By the eighth day he was free of symptoms, and two stool specimens collected one week later were free of the organism 3. The major antiparasitic property of MSM stems from its ability to bind to the mucosa and present a natural blocking interface between hosts and parasites. It's as though MSM puts down a coating on the mucosa, which parasites find impenetrable and can't cling to.
Unable to stick, the parasites are simply flushed out of the body 5, 9. In vitro research has shown the antiparasitic, antifungal and antibacterial action of MSM concentrations. According to Dr. Herschler, one can safely administer up to grams of MSM per kilogram of body weight on a daily basis.
A growing number of natural physicians are expressing concerns about parasites. It is becoming increasingly clear that they can be a continuous source of poisoning which can spread throughout the body and affect the immune system.
It is an intriguing thought that MSM may be nature's original means of protecting us against parasites. The sulfur-containing B vitamin biotin is a critical part of glucokinase, the enzyme involved in the utilization of the sugar glucose. Sulfur is also a component of insulin, the protein hormone secreted by the pancreas that is essential to carbohydrate metabolism. Lack of nutritional sulfur in the diet can result in low production of biologically active insulin. Studies indicate that MSM improves cellular glucose uptake by improving cell permeability, thus balancing blood sugar level and returning the pancreas to normal functioning 5.
Especially in combination with vitamin C, MSM has demonstrated remarkable ability to reduce or eliminate the incidence of muscle soreness, leg and back cramps. MSM is particularly successful with geriatric patients who have such cramps during the night or after long periods of inactivity. Many people with stiff muscles and joints have reported a marked improvement after using MSM for some time. Several cases have been reported of people who suffer from carpal tunnel syndrome, who have been cured by using MSM.
An elderly woman was slated to have an operation performed on both wrists. On the advice of the author she started using MSM. A month later her symptoms had all but disappeared, and the operation was no longer necessary. Athletes who compete vigorously can learn from trainers of million-dollar racehorses.
For many years and with great success, trainers administered MSM to their prize horses before a race to prevent muscle soreness, and afterwards to lessen the risk of cramping and improve physical recovery 4. In another study, twenty-one subjects with a history of constipation were given mg daily doses of MSM together with 1 gram of ascorbic acid.
All subjects with abnormal colon function returned to normal and remained normal while MSM was part of their diet 5. These studies indicate that MSM often gives more relief from stomach acidity and constipation than commonly prescribed medication.
Many people have reported that one of the most exciting and rewarding benefits of taking MSM is the prompt and continued relief from stomach acidity and constipation problems 7. MSM allows the body to more effectively take up oxygen. In the first place, it improves the elasticity of the lung cells and the permeability of long cell membranes, allowing more air to be breathed and oxygen to pass through the membranes into the blood stream.
Secondly, MSM prevents and corrects the clotting of red blood cells, allowing the blood to absorb more oxygen. Moreover, by improving the cell membrane permeability, cells throughout the body can take up more oxygen from the blood, and hence produce more energy.
People suffering from lung dysfunctions may benefit greatly from treatment with MSM. In one study, seven human subjects with respiratory deficiency were given MSM in amounts ranging from - 1.
Five had emphysema, and two had lung tumors with additional function impairment due to pleural fluid accumulation. Both were on radiation chemotherapy prior to including MSM in their diet, but without apparent benefit. Before and during the test period, the five subjects with emphysema walked a measured distance compatible with their physical capabilities. Within four weeks of beginning the ingestion of MSM, all emphysema sufferers had at least doubled their 'comfortable' walking distance.
The two subjects with lung tumors were assessed by attending physicians and nurses as more alert and with a better attitude than before the test. Most strikingly however, the lung fluid had disappeared during the first months of the test period 3. Many people using MSM have reported feeling better and stronger and capable of increased endurance. During a test with 14 persons using MSM for periods from seven months to over one year, none of them became ill 3.
One stress study involved two groups of 25 goldfish, which were removed from a large aquarium and placed in two identical, small aquariums. Movement confinement, temperature changes and marginal oxygenation stressed the fish in both aquariums equally. It is a common practice in intensive cattle breeding to add antibiotics to animal feed in order to promote growth and prevent the outbreak of stress-related diseases.
Animal products such as meat, milk and eggs contain residues of antibiotics, which pass into the consumer. The abundant usage of antibiotics is largely responsible for the creation of resistent bacteria strains. Today, increasing resistance of bacteria is considered one of the major threats to human health. It is an intriguing thought that adding MSM to animal feed might reduce stress and improve animal health to a level where the usage of antibiotics can be strongly reduced.
Sulfur is called nature's "beauty mineral" because it keeps skin smooth and youthful and hair glossy. Sulfur is necessary for the production of collagen and keratin, proteins necessary for the health and maintenance of skin, nails and hair 6.
Several experiments have shown that several dermatological disorders, including those that are allergy-related, respond favorably to a diet supplemented by MSM. Oral dosages of MSM have shown to be effective against acne, Rosaceae, and dry, scaly or itching skin 3.
When used topically in the form of an ointment or lotion, MSM is helpful in treating skin disorders including acne, psoriasis, eczema, dermatitis, dandruff, scabies, diaper rash and certain fungal infections 1, 6. Scars resulting from operations and from burns also respond well to topical application. New scars can heal so perfectly that they are almost invisible. Old scars, too, can improve markedly.
MSM is intended for everyone who appreciates good health. Sport enthusiasts and athletes can use it to improve their performance and speed up recovery after workouts. People with degenerative diseases can use it to drastically improve their health and quality of life. MSM is not a cure-all for solving every health problem. It is a food supplement that people in pre-modern societies received through their diets.
Most people today, however, suffer from chronic MSM deficiencies, due to its inability to endure the realities of the modern food and drink industry. MSM gives the body the tools it needs to better cure itself and maintain its vitality. MSM cannot do this by itself. The basis for good health is maintaining healthy living conditions, including a healthy and balanced diet, good lifestyle choices, and exercise. The optimal dosage depends on the nature and intensity of the complaints. In most cases, it is sufficient to take an initial dose of three 1-gram tablets twice daily.
Children ten and under should take a tablet twice daily, while those between ten and eighteen should take two tablets twice daily. People with serious ailments have been shown to benefit from higher dosages, up to four 1-gram tablets three times daily. Such a high dosage may be advised to fight parasital infections. Case studies have been reported in which patients did not show noticeable improvement until they received a daily dosage of 30 grams 6.
Such extreme dosages are not generally recommended for most people, although no negative effects were reported 3,6. People using MSM should make all changes to their dosage gradually. They should not increase their dose as long as detoxification symptoms persist.
Although uncommon, these symptoms may include nausea and headaches see below. MSM is best taken with a glass of water one half hour prior to eating. As it tends to stimulate energy levels, it is generally advisable not to take it prior to bed. MSM is similar in toxicity to water. When MSM was administered to human volunteers, no toxic effects were observed at intake levels of 1 gram per kg of body weight per day for 30 days.
Intravenous injections of 0. MSM has been widely tested as a food ingredient without any reports of allergic reactions. An unpublished Oregon Health Sciences University study of the long-term toxicity of MSM over a period of six months showed no toxic effects. More than 12, patients were treated with MSM at levels above two grams daily, without toxicity 8.
These symptoms may include mild forms of diarrhea, skin rash, headache and fatigue. After one week, these symptoms usually disappear. Generally, the stronger the symptoms are, the more toxins had been stored in the body, and the more MSM was needed for its purification.
If more moderate symptoms of detoxification are experienced, it may be advisable to reduce the dosage of MSM, and to gradually rebuild it once the symptoms disappear. Herschler, R. United States Patent 4,, Data, Mindell, E.
Enhance Your Health with Organic Sulfur. Ley, B. Owen, B. Why MSM?? Jacob, S. Moore, R. Meeting Richmond, V. Life Sciences , vol. Morton, J. Of the Soc. Munck-Khoe, L. Deel 1. Ortho 14 5 , Deel 2. Ortho 14 6 , Vos, R. Folia Orthica 1 : Lamers, H. Voor Integr. Nieuwenhuis, R. Dave Clark Member. Joined Jun 2, Messages 1, Inaut said:. GenericName86 Member. Joined Jun 30, Messages Thanks Inaut , msm looks pretty impressive there. I've used it on and off over the years and feel pretty good when using it.
I read once that too much though can deplete copper? GenericName86 said:. Somebody on the forum cleared that up for me. I think they found higher levels of zinc and copper in muscles during msm usage. It seems to make things more bio available and chelates the excess. Dave Clark i was taking a half teaspoon 3x a day. Didn't see any studies linked with it, also mentioned not to use msm if you have cbs pathway issues or hydrogen sulfide overgrowth. Peopleface Member. Joined Oct 23, Messages I just started using MSM only about two weeks ago perhaps less.
Right away I noticed the increased energy or type of focus that felt really good. At this time the skin on my hands and face is noticeably softer and more youthful appearing. Stanley Jacob references eleven case studies of patients suffering from osteoarthritis who experienced improved symptoms following supplementation with MSM [ 7 ].
Concurrent improvements were also noted in stiffness [ 18 , , ] and swelling [ ]. Furthermore, in the study conducted by Usha and Naidu [ ], MSM in combination with glucosamine potentiated the improvements in pain, pain intensity, and swelling.
Other human studies utilizing combination therapies report similar results. For instance, arthritis associated pain and stiffness was significantly improved through the use of Glucosamine, Chondroitin sulfate, and MSM GCM [ , ]. Only marginal improvements in pain and stiffness were observed when a GCM combination was supplemented on top of modifications to diet and exercise in sedentary obese women diagnosed with osteoarthritis OA [ ].
MSM was also shown to be effective in reducing arthritis pain when used in combination with boswellic acid [ ] and type II collagen [ ]. In addition to arthritis, MSM improves inflammation in a number of other conditions. For example, MSM attenuated cytokine expression in vivo for induced colitis [ ], lung injury [ ], and liver injury [ , ].
Hasegawa and colleagues [ ] reported that MSM was useful in protecting against UV-induced inflammation when applied topically and acute allergic inflammation after pre-treatment with a 2. MSM is effective at reducing other inflammatory pathologies in humans as well.
Additionally, MSM is also suggested to alleviate the symptoms of seasonal allergic rhinitis [ 22 , 23 ]. Though the reduction in systemic exercise-induced inflammation by MSM has been observed [ 24 ], human studies have not explored the inflammatory effects directly at the cartilage or synovium, as seen in the reduced synovitis inflammation in mice given MSM [ ].
Cartilage degradation has long been thought of as the driving force of osteoarthritis [ ]. Articular cartilage is characterized by a dense extracellular matrix ECM with little to no blood supply driving nutrient extraction from the adjacent synovial fluid [ ]. Histopathology of a rheumatoid arthritis RA rat model supplemented with a GCM combination demonstrated decreased synovium proliferation and the development of an irregular edge at the articular joint [ ].
Furthermore, MSM supplementation in OA mice significantly decreased cartilage surface degeneration [ ]. Interestingly, endogenous serum MSM becomes elevated in sheep post-meniscal destabilization caused osteoarthritis [ ]; however, the magnitude of this physiological response was not large enough to protect against cartilage erosion.
With the aforementioned improvements in inflammation and cartilage preservation, not surprisingly beneficial changes in overall physical function have also been noted through the use of subjective measurements [ 18 , 19 , , ]. Objective kinetic knee measurements following eccentric exercise-induced muscle damage were not conclusive but suggest that MSM may aid in maximal isometric knee extensor recovery [ ].
MSM has been used in a number of combination therapies with positive results. Supplementation with glucosamine, chondroitin sulfate, MSM, guava leaf extract, and Vitamin D improved physical function in patients with knee osteoarthritis based on the Japanese Knee OA Measure [ ].
A GCM supplement was successful in increasing functional ability and joint mobility [ ]. MSM in combination with boswellic acid was also shown to improve knee joint function as assessed through the Lequesne Index [ ].
Other studies exploring the uses of MSM in combination therapies failed to show significant improvements. In one such study in geriatric horses, a GCM combination supplement given orally for three months failed to show significant changes in gait characteristics [ ]. In humans, MSM and boswellic acid reduced the need for anti-inflammatory drugs but was not more effective than the placebo as a treatment for gonarthrosis [ ]. However, when a GCM combination supplement was administered in addition to dietary and exercise interventions, no significant improvements were noted when compared to the non-supplemented group [ ].
Subjects with lower back pain undergoing conventional physical therapy with supplementation of a glucosamine complex containing MSM reported an improvement in their quality of life [ ]. A systematic review of GCM supplements as a treatment for spinal degenerative joint disease and degenerative disc disease failed to come to a conclusion on efficacy due to the scarcity of quality literature [ ].
Prolonged strenuous exercise can result in muscle soreness caused by microtrauma to muscles and surrounding connective tissue leading to a local inflammatory response [ ]. MSM is alluded to be an effective agent against muscle soreness because of its anti-inflammatory effects as well as its possible sulfur contribution to connective tissue. Endurance exercise-induced muscle damage was reduced with MSM supplementation, as measured by creatine kinase [ ]. Pre-treatment with MSM reduced muscle soreness following strenuous resistance exercises [ , , ] and endurance exercise [ ].
In vitro studies suggest that MSM does not chemically neutralize ROS in stimulated neutrophils but instead suppresses mitochondrial generation of superoxide, hydrogen peroxide, and hypochlorous acid [ 97 ]. Treatment modalities for these animal studies were either an acute one time dose or pre-treatment prior to inducing injury [ , , ].
In humans, MSM pre-treatment prior to endurance exercise results in acute attenuation of induced protein oxidation [ , ], bilirubin [ , ], lipid peroxidation [ ], creatine kinase [ ], oxidized glutathione [ ], and uric acid [ ] and also an increase in total antioxidant capacity [ , ].
Following endurance exercise, reduced glutathione was elevated with 10 days of pre-treatment [ ] but was insignificantly affected by a single oral dose just prior to exercise [ ]. Pre-treatment with MSM in subjects undergoing resistance exercise exhibits more variability.
Supplementation for 28 days with 3. The longer period of supplementation may have allowed bioavailable MSM stores to reach a level where it could upregulate Nrf2 enough to produce a more significant rise in antioxidant enzymes. Combination therapies including MSM have become more popular recently, particularly with ethylenediaminetetraacetic acid EDTA due to the permeability enhancement provided by MSM [ ]. For instance, topical EDTA-MSM is effective at reducing oxidative damage in the form of protein-lipid aldehyde adducts [ , , ].
EDTA-MSM reduced lens opacification in diabetic cataract [ ] but was ineffective in reversing experimentally induced intraocular pressure in rats [ ]. Contrary to previous literature, Kantor et al. This conflicting result may be explained by the samples being collected at different points in the day, since the circadian clock can modulate this measure [ ]. In an evaluation of MSM on seasonal allergies, 2. All these improvements were maintained throughout the 30 days of supplementation.
A drawback of this study was the lack of reporting on pollen counts and a symptoms questionnaire [ ]. This was later corrected when Barrager and Schauss published the additional requested data [ 22 ]. Barrager et al. Since the initial patent awarded to Herschler in , MSM has been suggested to have therapeutic uses for the improvement of skin quality and texture by acting as a sulfur donor to keratin.
According to one final study report, MSM is non-irritating to the skin of rabbits via an occlusive patch. Another final study report indicated that MSM may be slightly irritating to skin of guinea pigs. Using a lotion containing EDTA and MSM, mild improvement in burn sites on rats were noticed following three days of topical application every 8 h [ ]. Skin appearance and condition after MSM treatment significantly improved as assessed by expert grading, instrumental analysis, and participant self-assessment [ ].
Human combination studies with four peeling sessions using pyruvic acid and MSM once every two weeks improved the degree of pigmentation of melisma, skin elasticity, and the degree of wrinkling [ ]. A combination treatment of silymarin and MSM proved useful in managing rosacea symptoms [ ]. A case study of a 44 year old man with severe X-linked type ichthyosis showed improvement of symptoms after four weeks of topical moisturizer containing amino acids, vitamins, antioxidants, and MSM [ ]. An emerging area of MSM research deals with the anti-cancer effect of the organosulfur compound.
In vitro studies using MSM alone or in combination have evaluated the metabolic and phenotypic effects of a number of cancer cell lines including breast [ , , , , , ], esophagus [ ], stomach [ ], liver [ , ], colon [ ], bladder [ 99 ], and skin cancers [ , ] with promising results.
MSM independently has been shown to be cytotoxic to cancer cells by inhibiting cell viability through the induction of cell cycle arrest [ , , ], necrosis [ ], or apoptosis [ , , , , ]. The reduced expression of IGF-1R and VEGF may help prevent the development of tumors by reducing the insulin-like growth factor-1 IGF-1 -mediated cell survival and proliferation pathways and preventing tumor-induced angiogenesis [ , ].
These metabolic alterations contribute to profound alterations at the cellular level as well. In vitro studies with cancer cell lines suggest that MSM has the ability to stimulate phenotypic changes more closely resembling non-cancerous cells.
Treatment with MSM results in the induction of contact inhibition and cell senescence [ , , , ], anchorage-dependent growth [ , ], reduced migration of metastatic lines [ , , , ], and normalized wound healing [ , ]. This could in part be attributed to the robust changes to cellular filaments, including the disassembly and indirect reassembly of microtubules [ ] and reorganization of actin localization [ ].
In vitro MSM studies have also been supported by additional xenograft and in vivo studies confirming the results. When cancer cells are xenotransplanted into animal models treated with MSM, tumor growth suppression has been observed [ 99 , , ], though two of these studies included a combination treatment of MSM and AG [ 99 ] or Tamoxifen [ ].
Previous studies also suggest that pre-treatment with MSM for approximately one week prior to inducing cancer in rats results in a significant reduction in the mean time to tumor onset [ , ]. Human trials with MSM as a cancer treatment have not been conducted to date; however, one study suggests that MSM use may be associated with a decreased risk of lung and colorectal cancer [ ].
In vitro and in vivo results warrant further investigation of MSM as a treatment for cancer. MSM appears to be well-tolerated and safe. A number of toxicity studies have been conducted in an array of animals including rats [ , , , , ], mice [ ], and dogs [ , ]. In a preliminary toxicity study report, a single mortality was reported in a female rat given an oral aqueous dose of Other technical reports indicate that mild skin and eye irritation have been observed when MSM is applied topically.
A summary of the toxicity studies is listed in Table 1. Much anecdotal evidence from web forums and videos exists regarding chronic MSM use and increased sensitivity to alcohol. Since other sulfur containing molecules, such as disulfiram, are used to combat alcoholism by causing adverse reactions when consuming alcohol [ ], it is worth mentioning there have been no studies to date examining the effects of MSM usage on alcohol metabolism or addiction pathways.
As mentioned previously, MSM readily crosses the blood brain barrier and becomes evenly distributed throughout the brain [ 76 , 77 , 78 , 79 , 80 ]; however, studies have not focused on the metabolic effects on the different neural pathways. Further studies are needed to assess the safety of MSM use with recreational alcohol use.
MSM is a naturally occurring organosulfur compound with broad biological effects. Human absorption and biosynthesis of this compound likely depends heavily on the co-metabolism between microbiota and host. Whether naturally produced or manufactured, MSM exhibits no biochemical differences in its ability to intermediate oxidative stress and inflammation.
This micronutrient is well tolerated for arthritis and a number of other conditions related to inflammation, physical function, and performance. Emerging research suggests that MSM may one day aid in the treatment of various types of cancer [ 49 , 99 , , , , , , , , , , , , , , ] or metabolic syndromes [ ].
All authors read and approved of the final manuscript. National Center for Biotechnology Information , U. Journal List Nutrients v. Published online Mar Matthew Butawan , 1 Rodney L. Benjamin , 2 and Richard J. Rodney L. Richard J. Author information Article notes Copyright and License information Disclaimer.
Received Dec 19; Accepted Mar This article has been cited by other articles in PMC. Abstract Methylsulfonylmethane MSM has become a popular dietary supplement used for a variety of purposes, including its most common use as an anti-inflammatory agent. Keywords: methylsulfonylmethane, MSM, dimethyl sulfone, inflammation, joint pain. Description and History of MSM Methylsulfonylmethane MSM is a naturally occurring organosulfur compound utilized as a complementary and alternative medicine CAM under a variety of names including dimethyl sulfone, methyl sulfone, sulfonylbismethane, organic sulfur, or crystalline dimethyl sulfoxide [ 1 ].
Mechanisms of Actions Due to its enhanced ability to penetrate membranes and permeate throughout the body, the full mechanistic function of MSM may involve a collection of cell types and is therefore difficult to elucidate. Immune Modulation Stress can trigger an acute response by the innate immune system and an ensuing adaptive immune response if the stressor is pathogenic.
Common Uses As a therapeutic agent, MSM utilizes its unique penetrability properties to alter physiological effects at the cellular and tissue levels. Arthritis and Inflammation Arthritis is an inflammatory condition of the joints that currently affects approximately 58 million adults, with an estimated increase to Cartilage Preservation Cartilage degradation has long been thought of as the driving force of osteoarthritis [ ].
Improve Range of Motion and Physical Function With the aforementioned improvements in inflammation and cartilage preservation, not surprisingly beneficial changes in overall physical function have also been noted through the use of subjective measurements [ 18 , 19 , , ]. To Reduce Muscle Soreness Associated with Exercise Prolonged strenuous exercise can result in muscle soreness caused by microtrauma to muscles and surrounding connective tissue leading to a local inflammatory response [ ].
Reduce Oxidative Stress In vitro studies suggest that MSM does not chemically neutralize ROS in stimulated neutrophils but instead suppresses mitochondrial generation of superoxide, hydrogen peroxide, and hypochlorous acid [ 97 ]. Improve Skin Quality and Texture Since the initial patent awarded to Herschler in , MSM has been suggested to have therapeutic uses for the improvement of skin quality and texture by acting as a sulfur donor to keratin.
Safety Profile MSM appears to be well-tolerated and safe. Open in a separate window. MSM and Alcohol Much anecdotal evidence from web forums and videos exists regarding chronic MSM use and increased sensitivity to alcohol. Conclusions MSM is a naturally occurring organosulfur compound with broad biological effects.
Acknowledgments Funding for this work was provided by The University of Memphis. Author Contributions M. Conflicts of Interest M. References 1. Bertken R. Crystalline dmso: DMSO 2. Arthritis Rheum. Clark T. Why are dimethyl sulfoxide and dimethyl sulfone such good solvents? Brayton C. Cornell Vet. Williams K. Metabolism of dimethyl sulfide, dimethyl sulfoxide, and dimethyl sulfone in the rabbit. Oxidation of dimethyl sulfoxide to dimethyl sulfone in the rabbit. Kocsis J. Biological effects of the metabolites of dimethyl sulfoxide.
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Pearson T. MSM actually plays a role with many functions in the body such as improving blood circulation and immune system. It also p romotes flexibility in muscles, tendons and connective tissues. Sulfur is perhaps one of the major nutrients in the body, since it is present in the amino acids that are the building blocks of proteins.
How to use MSM? Natural Sources. You can find MSM in some natural sources such as fresh fruits, vegetables and raw milk. Cooking heating will destroy most of the sulfur though. Dietary Supplements. Although standard recommendations do not exist, the dose varies from 2 grams to 10 grams per day.
Mix it together in a glass and drink immediately. I use this MSM powder in the morning in a glass of lukewarm lemon water on an empty stomach.
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